APPLICATIONS
Discovery Screening
Identify the right editing strategy early with confidence
Early discovery is where gene editing programs make their most important decisions. Multiple guides, editors and conditions are evaluated in parallel, often under pressure to move fast.
The currently available early-stage workflows rarely provide sufficient insight into genome-wide off-target risks in a time sensitive manner. This increases the chance of hidden liabilities and risks being carried forward.
INDUCE-seq® is designed to support discovery screening by enabling confident assessment of on- and off-target editing outcomes earlier.
The workflow is built to scale alongside modern screening approaches, supporting higher-throughput, automated laboratory environments without compromising data quality. This allows teams to focus resources on the most promising candidates while maintaining speed and consistency across experiments.
Challenges with current approaches
Reliance on predicted off-target sites rather than empirical data
Fragmented workflows requiring multiple assays
Limited scalability of genome-wide methods
Low confidence & hidden off-target risks leading to re-work
How we can help discovery teams
Compare multiple guides or conditions using the same assay
Generate empirical off-target data earlier in development
Reduce reliance on in silico prediction alone
Make more informed downstream selection decisions
Enabling drug discovery screening teams to:
Select with confidence
Identify guides and conditions with favorable on- and off-target profiles early
Ensure scalability
Generate data that remains relevant as programs move towards pre-clinical and IND-enabling stages
Improve efficiency
Replace fragmented screening workflows with a single, standardized approach
Reduce risk
Avoid advancing candidates with hidden genome-wide effects
Early access for discovery screening teams
Today, INDUCE-seq® is supporting later stage discovery and IND-enabling studies. We are working with selected partners to extend the platform to support higher-throughput formats, designed specifically for large-scale discovery.
How genome-wide measurements fit into discovery workflows
Provide feedback on throughput, data outputs and analysis needs
Shape future formats designed specifically for large-scale screening
Evaluating gene editing strategies in the discovery stage?
Get in touch to see how our platform can support your program needs
