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±õ±·¶Ù±«°ä·¡-²õ±ð±ç®: A New Standard for Genome-Wide DNA Break Characterization in Gene Editing
Despite the rapid evolution of CRISPR-Cas systems, base editors, and prime editors, the tools used to characterise off-target activity have not always kept pace. Many widely adopted methods rely on indirect readouts, PCR-amplified libraries, or fragmented multi-assay workflows. Others measure the final genomic outcome long after editing has occurred, rather than capturing the break event itself.